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Title : Tips Today Lorcaserin: The Latest Fda-Approved Obesity Drug
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Tips Today Lorcaserin: The Latest Fda-Approved Obesity Drug

The FDA of late approved a novel drug called lorcaserin (brand hollo Belviq) for the handling of obesity.  Lorcaserin causes an average of xiii lbs (5.8 kg) of weight loss over a year, compared to v lbs (2.2 kg) for placebo (1), which is less than the other of late approved drug Qsymia (formerly Qnexa; topiramate/phentermine).

Learning near obesity drugs is ever a expert chance to arrive at insight into the mechanisms that underlie the evolution in addition to reversal of obesity.  If you've been next this weblog for a while, y'all already conduct maintain a pretty expert approximate what organ this novel drug acts on.  Make your approximate in addition to read on!


Lorcaserin acts inward the brain, similar most other obesity drugs.  In fact, I would say this drug is i of the most straightforward of all of them.  It stimulates a specific neurotransmitter receptor, the serotonin 2C receptor, which is expressed inward several encephalon regions.  In particular, this receptor is expressed inward the hypothalamus, inward a key population of cells called POMC neurons.  The hypothalamus is the key regulator of trunk fatness, in addition to POMC neurons suppress nutrient intake in addition to lower obese volume when activated (2).  POMC neurons limited serotonin 2C receptors, in addition to activating them alongside serotonin, lorcaserin, or other drugs suppresses nutrient intake in addition to causes obese loss.   Research inward mice has shown that POMC neuron signaling is required for the effects of similar drugs, suggesting that they human activity through this pathway (3, 4).

POMC neurons are an of import role of the organisation that regulates trunk fatness inward humans, only at that topographic point are a disclose of other neuron populations that are too of import (including the of late characterized NOS1 neurons, which appear to hold upwards rattling important; 5).  Under normal circumstances, POMC neurons answer to circulating leptin, ghrelin, obese acids, in addition to other indicators of trunk unloose energy status, using these signals to residual nutrient intake, unloose energy expenditure in addition to obese storage.  Lorcaserin bypasses this in addition to stimulates POMC neurons directly, lowering nutrient intake in addition to the trunk obese "setpoint".  It is genuinely amazing that stimulating a few hundred tiny neurons inward the hypothalamus tin conduct maintain a meaning resultant on nutrient intake in addition to trunk fatness.  These neurons all together could jibe on the caput of a pin.

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