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Title : Tips Today Comment Published Inwards Nature
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Tips Today Comment Published Inwards Nature

I of late read an sentiment slice yesteryear Gary Taubes inward the scientific mag Nature, titled "Treat Obesity equally Physiology, non Physics", inward which he promoted NuSI in addition to repeated the declaration that obesity query is a "house of cards" because it focuses on calories in/out, at the expense of studying the "hormonal regulatory disorders" underlying obesity (1).  I wrote a missive of the alphabet to the editor inward reply to Taubes's commentary, which has been published in Nature (2).

I'm used to seeing these kinds of claims inward the pop press at this point, exactly to meet it published inward a scientific mag is galling (even if it's inward the sentiment section).  This is the equivalent of a someone who has never held an ax telling a grouping of lumberjacks they demand to focus on cutting trees.  It's component subdivision of a disturbing tendency of pop writers inward the low-carb in addition to Paleo the world attacking researchers, in addition to fifty-fifty entire fields of research, they convey picayune agreement of.  Of class this entirely applies to a minority of the community, exactly this argumentation vogue smells of desperation in addition to reflects poorly on the community equally a whole.

Our lab, along amongst many others approximately the world, studies the "hormonal regulatory disorders" underlying obesity.  We usage release energy repose (calories in/out) equally a query tool to larn at the underlying biology, which is the same approach NuSI itself is proposing.  The hormonal footing of obesity has ever been a fundamental focus of obesity research, in addition to efforts inward this direction convey entirely intensified inward recent decades.

The editors asked me to greatly shorten my missive of the alphabet for infinite reasons, in addition to they also watered it downwardly somewhat (journals don't similar to break things that undermine previously published material).  In whatever illustration I can't break it inward amount hither due to copyright concerns, exactly those who convey access tin read it (2).  However, I tin create fifty-fifty better: below, I'm copying the original version of the letter, earlier it was cutting yesteryear 75 percent:

      In his Dec 12 commentary inward Nature, Gary Taubes suggested that obesity query may travel a “house of cards” due to its focus on release energy balance, at the expense of studying the “hormonal regulatory disorders” underlying obesity (1).  Yet history shows that obesity query has been studying the “hormonal regulatory disorders” underlying obesity for to a greater extent than than 170 years, in addition to efforts inward this direction convey entirely intensified inward recent decades.
      In 1840, the High German doc Bernard Mohr published the get-go known trouble concern human relationship of human obesity associated amongst abnormalities of the basal hypothalamus (B. Mohr. Wschr Heilkd, 6:565–574. 1840).  Initially ascribed to pituitary dysfunction, lesion studies inward the 1920s-1950s established that the critical surface area was indeed the hypothalamus (3).  The 20th century saw the identification of multiple monogenic obesity models, such equally ob/ob mice, db/db mice, in addition to zucker obese rats, exhibiting phenotypes that some initially attributed to alterations inward adipose metabolism and/or insulin signaling (4).  Experiments inward the 1950s-1990s demonstrated convincingly that these animals lacked a circulating element (or its receptor) that regulates torso fatness yesteryear acting inward the hypothalamus—and that this element was non insulin (5).  In 1994, the veil was lifted amongst the regain of leptin—a hormone secreted yesteryear adipose tissue that acts primarily inward the hypothalamus to regulate torso fatness (6, 7).  The alterations inward adipose tissue metabolism of monogenic obesity inward rodents (and humans) were definitively attributed to original genetic defects inward the leptin-brain axis (6, 8).  It was after shown that obesity is associated amongst leptin resistance inward the brain, in addition to the physiological in addition to psychological “starvation response” to obese loss is mediated inward large component subdivision yesteryear a reduced leptin signal inward humans (9, 10, 11).  PubMed currently lists close 10,000 scientific publications containing the words “leptin” in addition to “obesity”, all of which convey been published inward the terminal nineteen years.
      Researchers never stopped studying the “hormonal regulatory disorders” underlying obesity, exactly their findings convey non supported Mr. Taubes’s carbohydrate-insulin hypothesis.

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